Name: Phaethon Philbrook
Year in Program: L3
Department: Human Genetics
Mentor: Dr. Augusto Ochoa
Hometown: Atlanta, GA
Education:
BS In Biology – Northeastern University
PhD in Human Genetics – LSU Health Sciences Center – New Orleans
Past Research Experience:
New England Inflammation and Tissue Protection Institute Boston, MA
Research Assistant in Biology and Pharmaceutical Science Department, Northeastern University: Exploring potential therapies to treat sepsis through the constitutive inhibition of anti-pathogen immune response. Research improvement of immunotherapy of cancer through the constitutive inhibition of anti-tumor immune response.
Acceleron Pharma Cambridge, MA
Co-Op Research Assistant in Preclinical Pharmacology Department: Researched drug therapeutic efficacy from TGFβ-Super family
Massachusetts General Hospital Boston, MA
Research Assistant in Mass General Nuclear Resonance Surgical Laboratory: Explored alternative care such as yoga and mindfulness as a potential therapeutic for stroke rehabilitation.
Massachusetts General Hospital Boston, MA
Research Assistant in Vaccine Immunotherapy Lab, Infectious Disease Department: Researched solutions for rapid wound healing via B-cell administration. Researched therapies for type one diabetes treatment by islet transfer and preventing graft rejection.
Arsenal Medical, Watertown, MA
Research Assistant for medical device start-up company: Researched use of foam as a potential postpartum hemorrhage solution in nations with healthcare disparities. Researched efficacy of bioresorbable stents.
Publications:
- Dean, MJ., Ochoa, JB., Sanchez-Pino, MD., Zabaleta, J., Garai, J., Del Valle, L.,
Wyczechowska, D., Baiamonte, LB., Philbrook, P., Majumder, R., Vander Heide, RS., Dunkenberger, L., Thylur, RP., Nossaman, B., Roberts,
WM., Chapple, AG., Wu, J., Hicks, C., Collins, J., Luke, B., Johnson, R., Koul, HK.,
Rees, CA., Morris, CR., Garcia-Diaz, J., Ochoa, AC. (2021) Severe COVID-19 Is Characterized
by an Impaired Type I Interferon Response and Elevated Levels of Arginase Producing
Granulocytic Myeloid Derived Suppressor Cells. Frontiers in Immunology 2021 Jul 14;12:695972.
- Yuan, G., Jankins, T.C., Patrick, C.G., Jr., Philbrook, P., Sears, O., Hatfield, S., Sitkovsky, M., Vasdev, N., Liang, S.H., Ondrechen, M.J., Pollastri MP, Jones GB (2017). Fluorinated Adenosine A2A Receptor Antagonists Inspired
by Preladenant as Potential Cancer Immunotherapeutics. International journal of medicinal
chemistry 2017, 4852537.
- Silva, M., Nguyen, T.H., Philbrook, P., Chu, M., Sears, O., Hatfield, S., Abbott, R.K., Kelsoe, G., and Sitkovsky, M.V.
(2017). Targeted Elimination of Immunodominant B Cells Drives the Germinal Center
Reaction toward Subdominant Epitopes. Cell reports 21, 3672-3680.
- Sethumadhavan, S., Silva, M., Philbrook, P., Nguyen, T., Hatfield, S.M., Ohta, A., and Sitkovsky, M.V. (2017). Hypoxia and hypoxia-inducible
factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor
cell recognition by T cells. PloS one 12, e0187314.
- Abbott, R.K., Silva, M., Labuda, J., Thayer, M., Cain, D.W., Philbrook, P., Sethumadhavan, S., Hatfield, S., Ohta, A., and Sitkovsky, M. (2017). The GS Protein-coupled
A2a Adenosine Receptor Controls T Cell Help in the Germinal Center. The Journal of
biological chemistry 292, 1211-1217.
- Abbott, R.K., Thayer, M., Labuda, J., Silva, M., Philbrook, P., Cain, D.W., Kojima, H., Hatfield, S., Sethumadhavan, S., Ohta, A., Reinherz EL, Kelsoe
G, Sitkovsky MV. (2016). Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination.
Journal of immunology (Baltimore, Md. : 1950) 197, 4014-4020.
- Hatfield, S.M., Kjaergaard, J., Lukashev, D., Schreiber, T.H., Belikoff, B., Abbott,
R., Sethumadhavan, S., Philbrook, P., Ko, K., Cannici, R., Thayer M, Rodig S, Kutok JL, Jackson EK, Karger B, Podack ER,
Ohta A, Sitkovksy MC (2015). Immunological mechanisms of the antitumor effects of
supplemental oxygenation. Science translational medicine 7, 277ra230.
- Hatfield, S.M., Kjaergaard, J., Lukashev, D., Belikoff, B., Schreiber, T.H., Sethumadhavan,
S., Abbott, R., Philbrook, P., Thayer, M., Shujia, D., Rodig S, Kutok JL, Ren J, Ohta A, Podack ER, Karger B, Jackson
EK, Sitkovsky MV. (2014). Systemic oxygenation weakens the hypoxia and hypoxia inducible
factor 1alpha-dependent and extracellular adenosine-mediated tumor protection. Journal
of molecular medicine (Berlin, Germany) 92, 1283-1292.
- Lazaridou, A., Philbrook, P., and Tzika, A.A. (2013). Yoga and mindfulness as therapeutic interventions for stroke
rehabilitation: a systematic review. Evidence-based complementary and alternative
medicine : eCAM 2013, 357108.
- Alimzhanov, M., Solban, N., Lee, M., Philbrook, P., Wang, X., Wei, L., Song, J., Signoretti, S., Pearsall, R.S., Sherman, M.L., Kumar, R., and Bhatt, RS. (2013). Abstract 5080: Inhibiting the ALK1/BMP9 signaling pathway with dalantercept as an antiangiogenic therapy. Cancer Research 73, 5080-5080.
Current Research Interest: Immunotherapies
Current Medical Interest: Immunology in the medical profession
Career Goal: Clinical and translational research
What makes you unique? Disastrous at song lyrics