Name: Nicholas D. Fried
Year in Program: L4
Department: Physiology
Mentor: Jason D. Gardner
Hometown: Millerstown, Pennsylvania
Education: University of Maine ‘16, BS in Animal & Veterinary Science
LSUHSC – New Orleans ’22, PhD in Physiology
Past Research Experience:
Genetic relatedness of Haemonchus contortus in sheep and wildlife reservoirs
Advisor: Dr. James A. Weber, University of Maine
Novel qPCR protocol for Borrelia burgdorferi identification in mammal tissue samples
Principle Investigators: Dr. Seungeun Han, Michigan State University; Dr. Jean Tsao,
Michigan State University
Titanium oxide zeolite and UV for the degradation of pharmaceutical contaminants
Principle Investigators: Patrick Sheldon, University of Maine; Dr. Howard Patterson,
University of Maine
Current Research Interest:
My research in the laboratory of Dr. Jason D. Gardner focuses on the cardiopulmonary and vascular health implications of nicotine and tobacco product use.
- Fried ND, Whitehead AK, Lazartigues E, Yue X, Gardner JD. Ovarian hormones do not mediate protection against pulmonary hypertension and right ventricular remodeling in female mice exposed to chronic, inhaled nicotine. Am J Physiol Heart Circ Physiol. 2022, 323: H941-H948. PMID: 36206053.
- Fried ND, Oakes JM, Whitehead AK, Lazartigues E, Yue X, Gardner JD. Nicotine and novel tobacco products drive adverse cardiac remodeling and dysfunction in preclinical studies. Front Cardiovasc Med. 2022, 9: 993617. PMID: 36277777.
- White AK*, Fried ND*, Li Z, Neelamegam K, Pearson CS, LaPenna KB, Sharp TE, Lefer DJ, Lazartigues E, Yue X, Gardner JD. Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction. Clin Sci. 2022, 136: 973-987. PMID: 35678315. *these authors contributed equally
- Fried ND, Morris TM, Whitehead AK, Lazartigues E, Yue X, Gardner JD. Angiotensin II type 1 receptor mediates pulmonary hypertension and right ventricular remodeling induced by inhaled nicotine. Am J Physiol Heart Circ Physiol. 2021, 320: H1526–H1534. PMID: 33577434. APSselect (April 2021) Award winner.
- Fried ND, Gardner JD. Heat-Not-Burn Tobacco Products: An Emerging Threat to Cardiovascular Health. Am J Physiol Heart Circ Physiol. 2020, 319: H1234–H1239. PMID: 33006919.
- Oakes JM*, Xu J*, Morris TM*, Fried ND, Pearson CS, Lobell TD, Gilpin NW, Lazartigues E, Gardner JD, Yue X. Effects of Chronic Nicotine Inhalation on Systemic and Pulmonary Blood Pressure and Right Ventricular Remodeling in Mice. Hypertension. 2020, 75:1305–1314. PMID: 32172623. *these authors contributed equally
Current Medical Interest: Consultation-liaison and addiction psychiatry. I am particularly interested in the complex interactions between mental health, substance use, and cardiovascular disease.
Career Goal: I hope to become a psychiatrist-scientist. I envision a career involving patient care, conducting research on nicotine and tobacco product use and cardiac psychiatry, and educating and mentoring future generations of physicians and researchers.
What makes you unique? I spent two summers living off-grid in Montana while vaccinating prairie dogs against Yersinia pestis, the bacteria which caused the Black Plague (https://www.greatfallstribune.com/story/news/local/2015/06/03/researchers-testing-plague-vaccine-prairie-dogs/28441567/).