Name: Kyle LaPenna
Year: L3
Hometown: Kinnelon, New Jersey
Education: B.S. Biology - The Pennsylvania State University
B.S. Toxicology - The Pennsylvania State University
Past Research Experience:
The Louisiana State University Health Sciences Center – New Orleans, LA
PhD Advisor: David J Lefer – Cardiovascular Center of Excellence, Pharmacology and Experimental Therapeutucs
- Dissertation: Nitric Oxide and Protein Nitrosylation Dynamics in Heart Failure with Preserved Ejection Fraction (HFpEF)
The Pennsylvania State University College of Medicine - Hershey, PA
Mentor: Pingnian He - Cellular and Molecular Physiology
- Studied endothelial cell barrier function in relation to red blood cell shear stress induced ATP release
- Investigated microparticle induced inflammation related to diabetes and other diseased states.
The Pennsylvania State University - University Park, PA
Mentor: Tim Miyashiro- Biochemistry and Molecular Biology
- Studied the host-microbe interaction regarding strain diversity of Vibrio fischeri on both colonization and persistence in the host light organ of Euprymna scolopes.
Research
https://scholar.google.com/citations?user=WyXHo18AAAAJ&hl=en&oi=ao
Publications:
- Li Z, Xia H, Sharp TE 3rd, LaPenna KB, Elrod JW, Casin KM, Liu K, Calvert JW, Chau VQ, Salloum FN, Xu S, Xian M, Nagahara N, Goodchild TT, Lefer DJ. Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure. Circ Res. 2022 Jun 14. doi: 10.1161/CIRCRESAHA.121.319817
- Whitehead AK, Fried ND, Li Z, Neelamegam K, Pearson CS, LaPenna KB, Sharp T, Lefer DJ, Lazartigues E, Gardner JD, Yue X. Alpha7 Nicotinic Acetylcholine Receptor Mediates Chronic Nicotine Inhalation-Induced Cardiopulmonary Dysfunction. Clin Sci (Lond). 2022. doi: 10.1042/CS20220083.
- LaPenna KB, Werthmann DW, Rabito FA, Baker JW, Cook MW. Elevation of Serum Copper in the New Orleans Bariatric Clinic Population: the Norm or Geographically Localized Findings? Obes Surg. 2021. Aug 18. doi: 10.1007/s11695-021-05666-6
- LaPenna KB, Polhemus DJ, Doiron JE, Hidalgo HA, Li Z, Lefer DJ. Hydrogen Sulfide as a Potential Therapy for Heart Failure - Past, Present and Future. Antioxidants.2021.March17;doi:10.3390/antiox10030485.
- Chen YC, Dinavahi SS, Feng Q, Gowda R, Ramisetti S, Xia X, LaPenna KB, Chirasani VR, Cho SH, Hafenstein SL, Battu MB, Berg A, Sharma AK, Kirchhausen T, Dokholyan NV, Amin S, He P, Robertson GP. Activating sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibting cancer metastasis. CancerLett.2021Feb15; doi:10.1016/j.canlet.2021.01.004.
- Feng Q, Stork CJ, Xu S, Yuan D, Xia X, LaPenna KB, Guo G, Sun H, Xu LC, Siedlecki C, Brundage K, Sheaffer N, Schell TD, He P. Increased circulating microparticles in streptozotocin-induced diabetes propagate inflammation contributing to microvascular dysfunction. J Physiol. 2018Dec11; doi:10.1113/JP277312.
- Gao F, Lucke-Wold BP, Li X, Logsdon AF, Xu LC, Xu S, LaPenna KB, Wang H, Talukder MAH, Siedlecki CA, Huber JD, Rosen CL, He P. Reduction of Endothelial Nitric Oxide Increases the Adhesiveness of Constitutive Endothelial Membrane ICAM-1 through Src-Mediated Phosphorylation.FrontPhysiol.2018Jan10;doi:10.3389/fphys.2017.01124.
- Xu S, Li X, LaPenna KB, Yokota SD, Huke S, He P. New Insights into sheer stress-induced endothelial signaling and barrier function: cell-free fluid versus blood flow. Cardiovasc Res. 2017Apr1;doi:10.1093/cvr/cvx021.
- Sun Y, LaSota ED, Cecere AG, LaPenna KB, Larios-Valencia J, Wollenberg MS, Miyashiro T. Intraspecific competition impacts Vibrio fischeri strain diversity during initial colonization of the squid light organ. Appl Environ Microbiol. 2016 May 2; doi: 10.1128/AEM.04143-15.
Current research interest: Vascular Permeability, Cardiology, Microbiome
Current medical interest: Cardiology and Gastroenterology
Career goal: A physician-scientist that can help drive forward novel therapeutics for the benefit of patients.
What makes me unique: I have been a background extra in at least 4 movies and still don’t have an IMDb page…
What makes me common: My belief that Penn State football could take LSU any day of the week.